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Multicentric Reticulohistiocytosis

Multicentric reticulohistiocytosis is a rare systemic disease with proliferation of histiocytes {Histiocytes are cells of the immune system that ingest foreign antigens to protect against infection). These histiocytes attacks its own body causing destructive Polyarthritis and skin lesions.

Symptoms of Multicentric Reticulohistiocytosis

  • Multiple joints are involved, including the interphalangeal joints of the fingers, knees, shoulders, wrists, hips, ankles, feet, elbows, spine and temporomandibular joints.

Multicentric reticulohistiocytosis can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.


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