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Inflammation and cells

There are different types of cells involved with inflammation.

Cells associated with acute inflammation and chronic inflammation.

Inflammation is a process by which the body’s white blood cells and chemicals protect us from infection and foreign substances such as bacteria and viruses.

There are two types of cells that are typically found in acute inflammation. These are neutrophils cells and mononuclear cells.

There are two types of cells that are typically found in chronic inflammation. These are mononuclear cells and  fibroblasts

Neutrophils cells - Neutrophils are the most abundant type of white blood cells in mammals and form an essential part of the innate immune system. They are primary type of white blood cell involved in inflammation. Neutrophils are a type of granulocyte, also known as a polymorphonuclear leukocyte.

Mononuclear cells - These blood cells are a critical component in the immune system to fight infection and adapt to intruders. There are 4 types of mononuclear cells monocytes, macrophages, lymphocytes and  plasma cells

  • Monocytes - Monocyte is a type of white blood cell and is part of the human body's immune system. Monocytes play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under normal states, and (2) in response to inflammation signals, monocytes can move quickly (approx. 8-12 hours) to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response.

  • Macrophages - the term "macrophage" conjures images of a hungry white blood cell gobbling invading bacteria. However, macrophages do much more than that: Not only do they act as antimicrobial warriors, they also play critical roles in immune regulation and wound-healing. They can respond to a variety of cellular signals and change their physiology in response to local cues.

  • Lymphocytes - lymphocyte is a type of white blood cell present in the blood. When the general defense systems of the body have been penetrated by dangerous invading microorganisms, lymphocytes help provide a specific response to attack the invading organisms. Lymphocytes help to protect the body against tumors (tissues that grow more rapidly than normal). However, lymphocytes can also cause the rejection of tissues during organ transplants because they interpret these tissues as foreign invaders.

  • Plasma cells - white blood cells which produce large volumes of antibodies. They are transported by the blood plasma and the lymphatic system. Like all blood cells, plasma cells ultimately originate in the bone marrow; however, these cells leave the bone marrow as B cells, before terminal differentiation into plasma cells, normally in lymph nodes.

Fibroblast - A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework for animal tissues, and plays a critical role in wound healing. Fibroblasts are the most common cells of connective tissue in animals.

 

 

 

   

   

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Arthritis can develop as a result of an infection. For example, bacteria that cause gonorrhea or Lyme disease can cause arthritis. Infectious arthritis can cause serious damage, but usually clears up completely with antibiotics. Scleroderma is a systemic disease that involves the skin, but may include problems with blood vessels, joints, and internal organs. Fibromyalgia syndrome is soft-tissue rheumatism that doesn't lead to joint deformity, but affects an estimated 5 million Americans, mostly women. The approximate number of cases in the United States of some common forms of arthritis.

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Most of the information in the site is compiled by editors from information provided by the National Institutes of Health. We are in the process of updating our pages. In the past we have not made reference to the source for information provide by our editors. In the next few weeks we hope to have all our pages marked as to the source.

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