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Chronic inflammation

 

Chronic inflammation prolonged and persistent inflammation marked chiefly by new connective tissue formation; it may be a continuation of an acute form or a prolonged low-grade form. This ongoing inflammatory response causes progressive damage to the body that leads to a variety of diseases.

Inflammation is part of your bodies way of defending itself against attack. Your immune system is designed to turn on the inflammatory process in response to an attack on the body. Chronic inflammation is when this never gets turned off. A problem is created when the body is always on attack mode when there is nothing to foreign to attack. When the cells, chemicals and proteins created  by the inflammatory response of the immune system are created they will find something to attack. If they can not find something foreign to attack then they end up attacking the bodies on cells.

Chronic inflammation may lead to many medical conditions such as

  • Inflammatory arthritis
  • Heart disease
  • Diabetes.
  • High cholesterol
  • High blood pressure
  • Atherosclerosis
  • Alzheimer's disease
  • Macular degeneration
  • Certain types of cancer.


Created May 11, 2011



 

 

Comparison between acute and chronic inflammation:

  Acute Chronic
Causative agent Pathogens, injured tissues Persistent acute inflammation due to non-degradable pathogens, persistent foreign bodies, or autoimmune reactions
Major cells involved Neutrophils, mononuclear cells (monocytes, macrophages) Mononuclear cells (monocytes, macrophages, lymphocytes, plasma cells), fibroblasts
Primary mediators Vasoactive amines, eicosanoids IFN-γ and other cytokines, growth factors, reactive oxygen species, hydrolytic enzymes
Onset Immediate Delayed
Duration Few days Up to many months, or years
Outcomes Resolution, abscess formation, chronic inflammation Tissue destruction, fibrosis
 

 

 

   

   

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Arthritis can develop as a result of an infection. For example, bacteria that cause gonorrhea or Lyme disease can cause arthritis. Infectious arthritis can cause serious damage, but usually clears up completely with antibiotics. Scleroderma is a systemic disease that involves the skin, but may include problems with blood vessels, joints, and internal organs. Fibromyalgia syndrome is soft-tissue rheumatism that doesn't lead to joint deformity, but affects an estimated 5 million Americans, mostly women. The approximate number of cases in the United States of some common forms of arthritis.

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Most of the information in the site is compiled by editors from information provided by the National Institutes of Health. We are in the process of updating our pages. In the past we have not made reference to the source for information provide by our editors. In the next few weeks we hope to have all our pages marked as to the source.

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