Ankylosing Spondylitis Causes
The cause of ankylosing spondilitis as with all autoimmune diseases is unknown, but genetic factors seem to play a role. The disease starts with intermittent hip and/or lower-back pain that is worse at night, in the morning, or after inactivity. While the cause is unknown doctors have noticed that some things can trigger it.
Back pain begins in the sacroiliac joint (between the pelvis and the spine) and may progress to include the lumbosacral spine and the thoracic spine (chest portion of the spine).
Pain may be eased by assuming a bent posture. Limited expansion of the chest occurs
because of the involvement of the joints between the ribs. The symptoms may worsen, go
into remission, or stop at any stage.
The disease most frequently begins between age 20 and 40, but may begin before age 10. It affects more males than females. Risk factors include a family history of ankylosing spondylitis and male gender. About 0.21% of Americans over age 15 are affected.
Ankylosing spondylitis may be triggered by certain types of bacterial or viral infections that activate an immune response that does not shut off after the infection is healed. The immune system then attacks the body's own tissue. A disorder caused by the body's own immune system is called an autoimmune disease.
Genetic markers are protein molecules found on the surfaces of cells. The HLA markers enable the body's immune system to distinguish between "self" and "other."
Modified 6-10-2013 Information compiled from the National Institutes of Health
This web site is intended for your own informational purposes only. No person or entity associated with this web site purports to be engaging in the practice of medicine through this medium. The information you receive is not intended as a substitute for the advice of a physician or other health care professional. If you have an illness or medical problem, contact your health care provider.
Arthritis-Symptom.com is an informational out reach of the Consumer Health Information Network. It is our goal to provide up to date information about arthritis and other inflammatory and bone conditions in a easy to understand format.